Quantitative MDCT and MRI assessment of hepatic steatosis in genotype 4 chronic hepatitis C patients with fibrosis

Abstract Background Hepatic steatosis has been shown to worsen the course of liver disease in chronic hepatitis C (CHC) patients, and it may reduce efficacy antiviral therapy accelerate progression. In this cross-sectional study, we aimed evaluate role multidetector computed tomography magnetic resonance imaging (MRI) quantitative assessment grading hepatic association between fibrosis Egyptian genotype 4-CHC (G4-CHC) patients. Results Histopathological was found 70.3% 155 No correlation CT ratio pathological steatosis. Proton density fat fraction, T1-fat percentage correlated with histological ( r = 0.953, p < 0.001; 0.380, 0.027 0.384, 0.025, respectively). An agreement by histology 1H-MRS 74.2% Compared other MRI modalities, proton fraction had highest area under receiver operating characteristic curve (AUC), 0.910, 0.931, 0.975 for mild, moderate, severe steatosis, respectively. The cutoff best ability predict > 4.95 a (AUC 0.958) 95.8% sensitivity, 90% specificity, 78.5% positive predictive value, 96.1% negative value. Conclusion good diagnostic performance predicting G4-CHC hence, offer useful noninvasive modality clinical applicability, especially those where biopsy cannot be done.